Jon yew dell biography images

The vertebrate immune system evolved in response to the threat posed by viruses.

Natasha caplan nih

An astounding variety of viruses are recognized as human pathogens. Spotlight Seminar Series. This talk will illustrate how, in over 4 decades of research, cell biology, virology, and immunology can be combined to dissect a medically important immune effector mechanism. View Organizer Website. Google Calendar. View additional Principal Investigators in Virology.

Biography Dr. In , Dr. Arnold Levine for his undergraduate thesis on immune recognition of virus-transformed cells. Walter Gerhard on using monoclonal antibodies to understand influenza A virus hemagglutinin antigenicity and function. Many cellular peptides, and likely nearly all viral peptides, derive from rapidly degraded proteins, which consist of defective ribosomal products DRiPs and short-lived proteins SLiPs.

Most non-canonical proteins uniquely populate the proteome or immunopeptidome. View Site. Necessary Necessary. View additional Principal Investigators in Cell Biology.

Kathryn zoon

C1q enables influenza hemagglutinin stem binding antibodies to block viral attachment and broadens the antibody escape repertoire. Cell Rep. The immune system like every biological system is not perfect, and overzealous anti-viral responses frequently contribute to viral diseases. Organizer Spotlight Seminar Series events scilifelab.

Yewdell received an A. He received an M. View additional Principal Investigators in Immunology. I will describe the nature of a number of influenza virus DRiPs and how ribosome profiling facilitates the identification of peptides derived from non-canonically translated cellular DRiPs. Content Responsible: Alice Sollazzo alice.

I will present a model to explain how peptide generation avoids the law of mass action to generate a highly diverse peptide repertoire immunopeptidome that enables pathogen and tumor recognition. The mission of the Cellular Biology Section is to extend basic understanding of the interaction between the host and viruses and to use viruses as tools to better understand cell biology.

The roster lengthens as humans come into more intimate contact with animal reservoirs harboring novel viruses and new technologies reveal human viruses that previously escaped detection. David Lane at the Imperial College in London, studying the newly discovered p53 protein. Jonathan Wilson Yewdell, M.